## Abstract An efficient and reliable method for the preparation of bitritiated‐methylthioribose from a suitably protected 5‐ketoazido‐ribose derivative has been developed. This compound is an essential component in the assay of the microbial enzyme methylthioribose kinase, which is involved in the
Synthesis of 5-Heteroarylazulenes: First Selective Electrophilic Substitution at the 5-Position of Azulene.
✍ Scribed by Taku Shoji; Shunji Ito; Masataka Watanabe; Kozo Toyota; Masafumi Yasunami; Noboru Morita
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 24 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Reactions of methyl pyrazole‐4‐carboxylates 4b‐d with __N__‐chlorosuccinimide under heating conditions without a solvent gave methyl 3,5‐dichloro‐1‐methylpyrazole‐4‐carboxylate 4a in good yields. The reaction of 4a with sodium hydrosulfide led to a nucleophilic substitution on the 5‐pos