Synthesis of 5-dialkylaminothiocarbonylthiobarbituric acids and 5-diethyiaminothiocarbonylthio-6-aminouracil

✍ Scribed by Ojars Y A. Neilands; Ineta Sudmale; Barbara Schnell; Krassimira Georgieva; Thomas Kappe

• Publisher: Journal of Heterocyclic Chemistry
• Year: 1998
• Tongue: English
• Weight: 286 KB
• Volume: 35
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570350129

✦ Synopsis

The title compounds are obtained by three different methods. The aminothiocarbonylthiolation of barbituric acids 1 and aminouracil (5) can be accomplished in one step by reaction with thiuram disulfides in the presence of potassium carbonate. On the other hand, compounds (\mathbf{4}) can be obtained via the salt of chloro derivative (\mathbf{2}) or the corresponding iodonium ylides 3 . The aminouracil derivative 7 was obtained in a similar fashion from 5 directly or via iodonium betaine 6 .