Synthesis of 5-amino-2-selenoxo-1,3-imidazole-4-carboselenoamides by the reaction of isoselenocyanates with aminoacetonitriles
β Scribed by Nobuhito Tanahashi; Mamoru Koketsu
- Book ID
- 113929705
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 944 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The reaction of __S__βmethylisothiosemicarbazide hydroiodide (=__S__βmethyl hydrazinecarboximidothioate hydroiodide; **1**), prepared from thiosemicarbazide by treatment with MeI in EtOH, and aryl isoselenocyanates **5** in CH~2~Cl~2~ affords 3__H__β1,2,4βtriazoleβ3βselone derivatives *
An efficient and regioselective synthesis of 2-imino-1,3-selenazolidin-4-ones and 2-amino-1,3,4-selenadiazin-5-ones was achieved via one-pot reaction of isoselenocyanates, hydrazines, and ethyl chloroacetate or chloroacetyl chloride, respectively. Plausible mechanisms for these transformations were