One-Pot Synthesis of 2-Imino-1,3-selenazolidines by Reaction of Isoselenocyanates with Propargylamine
โ Scribed by Koketsu, Mamoru; Sakai, Tsutomu; Kiyokuni, Takashi; R. Garud, Dinesh; Ando, Hiromune; Ishihara, Hideharu
- Book ID
- 111875904
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 688 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0385-5414
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An efficient and regioselective synthesis of 2-imino-1,3-selenazolidin-4-ones and 2-amino-1,3,4-selenadiazin-5-ones was achieved via one-pot reaction of isoselenocyanates, hydrazines, and ethyl chloroacetate or chloroacetyl chloride, respectively. Plausible mechanisms for these transformations were
## Abstract Reaction of isoselenocyanates with hydrazine or aryl hydrazines generates the corresponding selenosemicarbazides which are coupled with ethyl chloroacetate to yield 1,3โselenazolidinโ4โones (III) and (VI).