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Synthesis of 5-, 6- and 7-substituted-2-aminoquinolines as SH3 domain ligands

โœ Scribed by Inglis, Steven; Jones, Rhiannon; Fritz, Daniel; Stojkoski, Cvetan; Booker, Grant; Pyke, Simon


Book ID
111696920
Publisher
Royal Society of Chemistry
Year
2005
Tongue
English
Weight
433 KB
Volume
3
Category
Article
ISSN
1477-0520

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โœ Simon J. Teague; Simon Barber ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 525 KB

Methods for the synthesis of 5-cyano-7-hydroxy-2-carboxybenzofurans bearing a variety of substituents at the 6-position are outlined. The scope and limitations of lithiation processes, electrophilic substitutions, and pericyclic reactions are investigated.