Synthesis of [4,4,4-2H3]butanoic acid
✍ Scribed by Frans R. Visser
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 150 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
The synthesis of [4,4,4-2H31butanoic acid with 10% yield from deuterated acetic acid is described. The structure is confirmed by n.m.r. and mass spectroscopy and the percentage of labelling is established as >98.5%
[2H3lbutanoic acid.
📜 SIMILAR VOLUMES
The synthesis of the title compound is described. It involves base catalyzed substitution of deuterium for hydrogen in 3-p- -chlorophenylglutaric acid which is subsequently transformed to baclofen. The overall yield is 80%. ## INTRODUCTION AND DISCUSSION In order to develop a mass fragmentographi
Alkylation o f the dianion o f 3-(phenylsulfinyl)propanol with [ Cliodomethane and subsequent reductive fission of the sulfoxides gave [4-13C]butanol that was oxidized to give [4-13C]butanoic acid.
## Abstract (3R)‐3‐(4‐Fluorophenylsulfonamido)‐1, 2, 3, 4‐tetrahydro‐9‐[4‐^3^H]carbazolepropanoic acid ([^3^H]BAY u 3405) (5) was synthesized by catalytic reduction of (3R)‐3‐(4‐fluorophenylsulfon‐amido)‐4‐oxo‐1, 2, 3, 4‐tetrahydro‐9‐carbazolepropanoic acid (4) with tritium. The precursor (4) was p