𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of (3R)-3-(4-fluorophenylsulfonamido)-1, 2, 3, 4-tetrahydro-9-[4-3H]carbazolepropanoic acid

✍ Scribed by Ulrich Pleiß; Martin Radtke; Peter Schmitt

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
212 KB
Volume
28
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

(3R)‐3‐(4‐Fluorophenylsulfonamido)‐1, 2, 3, 4‐tetrahydro‐9‐[4‐^3^H]carbazolepropanoic acid ([^3^H]BAY u 3405) (5) was synthesized by catalytic reduction of (3R)‐3‐(4‐fluorophenylsulfon‐amido)‐4‐oxo‐1, 2, 3, 4‐tetrahydro‐9‐carbazolepropanoic acid (4) with tritium. The precursor (4) was prepared by esterification and following oxidation of BAY u 3405 with 2, 3‐dichloro‐5, 6‐dicyano‐p‐benzoquinone. ^3^H NMR analysis of the final product showed the formation of [4α‐^3^H]BAY u 3405 and [4ß‐^3^H]BAY u 3405 in a ratio of 1: 1.

📜 SIMILAR VOLUMES

Synthesis of (+)-(3R)-3-(4-fluorophenyls
Synthesis of (+)-(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-[5,6,7,8,12,13-U-14C]carbazolepropanoic acid, [14C]BAY u 3405
✍ Martin Radtke; Michael Boberg; Ulrich Pleiss; Ulrich Rosentreter 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 382 KB 👁 1 views

## Abstract The title compound [^14^C]BAY u 3405 (1) was synthesized as part of 8‐step sequence. Starting from [U‐^14^C]aniline hydrogensulfate the final product 1 was obtained with a specific activity of 741 MBq/mmol (20 mCi/mmol) and a radiochemical purity of > 98% in an overall yield of 6 and 10

Indoles, IV 9-Substituted 4,9-Dihydropyr
Indoles, IV 9-Substituted 4,9-Dihydropyrano[3,4-b]indol-1(3H)-ones - Synthesis and Conversion into 2,3,4,9-Tetrahydro- 1H-pyrido-[3,4-b]indoles
✍ Adel A. El-Gendy; Jochen Lehmann 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB 👁 1 views

Eingegangen am 31. Oktober 1986 Pyrano[ 3,4-blindolones 3a-d are available from a-ethoxyalyllactones la, c and disubstituted hydrazines 2a, b without isolation of intermediates. In a two-phase system, however, the intermediate hydrazones 4a, c can be isolated. Conversion of 3a-d into P-carbolines wa

1.2.4.5-Tetrahydro-3H-3-benzosilepine
1.2.4.5-Tetrahydro-3H-3-benzosilepine
✍ Birkofer, Leonhard ;Krämer, Erich 📂 Article 📅 1969 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 253 KB 👁 1 views
ChemInform Abstract: Synthesis of 3-Subs
ChemInform Abstract: Synthesis of 3-Substituted-2,3,4,5-tetrahydro-1H-naphth(1,2-d) imidazole-2,4,5-triones and 1-Substituted-2,3,4,9-tetrahydro-1H-naphth( 2,3-d)imidazole-2,4,9-triones.
✍ S. BOZZINI; P. NITTI; G. PITACCO; A. PIZZIOLI; C. RUSSO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v