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Synthesis of (+)-(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-[5,6,7,8,12,13-U-14C]carbazolepropanoic acid, [14C]BAY u 3405

✍ Scribed by Martin Radtke; Michael Boberg; Ulrich Pleiss; Ulrich Rosentreter

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
382 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The title compound [^14^C]BAY u 3405 (1) was synthesized as part of 8‐step sequence. Starting from [U‐^14^C]aniline hydrogensulfate the final product 1 was obtained with a specific activity of 741 MBq/mmol (20 mCi/mmol) and a radiochemical purity of > 98% in an overall yield of 6 and 10% depending on the method.

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