𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 4,17-diazasteroid inhibitors of human 5α-reductase

✍ Scribed by Jacek W. Morzycki; Zenon z.xl;Lotowski; Agnieszka Z. Wilczewska; J. Darren Stuart

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
566 KB
Volume
4
Category
Article
ISSN
0968-0896

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis of the 17-aza isomer of finasteride is described. With the side chain amide group of the compound existing in the Z configuration the structure is similar to one of the two favored conformations of finasteride. A series of 4.17-diazasteroids was assayed against the isoenzymes of human 5~-reductase.

📜 SIMILAR VOLUMES

Steroidal nitrone inhibitors of 5α-reduc
Steroidal nitrone inhibitors of 5α-reductase
✍ Andrea J Robinson; Indawati DeLucca; Spencer Drummond; George A Boswell 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 106 KB

This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i

Synthesis of carbon-14 and tritiated ste
Synthesis of carbon-14 and tritiated steroidal 5α-reductase inhibitors
✍ Arthur Y. L. Shu; J. Richard Heys 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 414 KB

## Abstract 17β‐[N‐(1,1‐Dimethylethyl)carbamoyl]androsta‐3,5‐diene‐4‐^14^C‐3‐carboxylic acid ([^14^C]SK&F 105657) was prepared __via__ a three‐step sequence (t‐butyl amidation, triflation and carbomethoxylation) starting from androst‐4‐en‐3‐one‐4‐^14^C‐17β‐carboxylic acid. Its A‐ring aromatic analo