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Synthesis of 4-Trifluoromethylpyrido[2,3-a]pyrimidin-2-ones Utilizing Activated Alkynoates.

โœ Scribed by Geraldine C. B. Harriman; Shannon Chi; Min Zhang; Andrea Crowe; Robert A. Bennett; Ian Parsons


Book ID
101948977
Publisher
John Wiley and Sons
Year
2003
Weight
106 KB
Volume
34
Category
Article
ISSN
0931-7597

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Abstract

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of 4-trifluoromethylpyrido[1,2
โœ Geraldine C.B Harriman; Shannon Chi; Min Zhang; Andrea Crowe; Robert A Bennett; ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 173 KB

The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mi

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