The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mi
โฆ LIBER โฆ
Synthesis of 4-Trifluoromethylpyrido[2,3-a]pyrimidin-2-ones Utilizing Activated Alkynoates.
โ Scribed by Geraldine C. B. Harriman; Shannon Chi; Min Zhang; Andrea Crowe; Robert A. Bennett; Ian Parsons
- Book ID
- 101948977
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 106 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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