Synthesis of 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-ones utilizing activated alkynoates

✍ Scribed by Geraldine C.B Harriman; Shannon Chi; Min Zhang; Andrea Crowe; Robert A Bennett; Ian Parsons

• Book ID: 104253489
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 173 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00700-7

✦ Synopsis

The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mild conditions.