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Synthesis of derivatives of pyrazino[1,2-a]pyrimidin-4-ones

✍ Scribed by F. Dennin; D. Blondeau; H. Sliwa


Book ID
112129758
Publisher
Journal of Heterocyclic Chemistry
Year
1990
Tongue
English
Weight
305 KB
Volume
27
Category
Article
ISSN
0022-152X

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Synthesis of 4-trifluoromethylpyrido[1,2
✍ Geraldine C.B Harriman; Shannon Chi; Min Zhang; Andrea Crowe; Robert A Bennett; πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 173 KB

The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mi