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Synthesis of 4-thia[5-13C]lysine

✍ Scribed by Amarendra Nath Maity; Shyue-Chu Ke

Publisher: John Wiley and Sons
Year: 2011
Tongue: French
Weight: 150 KB
Volume: 54
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1893

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✦ Synopsis

This report describes the synthesis of 4‐thia[5‐^13^C]lysine, an isotopomer of 4‐thialysine that is an analog of lysine. It was synthesized from 2‐amino[1‐^13^C]ethanol hydrochloride (1) in two steps. In the first step, 1 was converted to 2‐bromo[2‐^13^C]ethylamine hydrobromide (2). The reaction of cysteine with 2 in basic condition followed by acidification afforded 4‐thia[5‐^13^C]lysine hydrochloride (3).

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