✦ LIBER ✦

Synthesis of 4-substituted 2-aminopyrrolo[2,3-d]pyrimidine 2′,3′-dideoxyribonucleosides

✍ Scribed by Seela, Frank ;Muth, Heinz-Peter

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 578 KB
Volume: 1990
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199019900141

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✦ Synopsis

Abstract

A number of new 2‐aminopyrrolo[2,3‐d]pyrimidine N‐7‐(2′,3′‐dideoxyribonucleosides) (11–13 and 15) were synthesized. These are related to 7‐deaza‐2′,3′‐dideoxyguanosine (14), but carry various substituents at C‐4. 2‐Amino‐4‐chloro‐7‐(2′,3′‐dideoxy‐β‐D‐glycero‐pentofuranosyl)‐7__H__‐pyrrolo[2,3‐d]‐pyrimidine (3) was used as a common intermediate, and was obtained from the corresponding 2′‐deoxyribonucleoside 4 by selective silylation of 5′‐OH and Barton deoxygenation of 3′‐OH.

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