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Convenient synthesis of substituted 2-(2-iminocoumarin-3-yl)thieno[2,3-d]pyrimidin-4-ones

✍ Scribed by Pavlo E. Shynkarenko; Sergiy V. Vlasov; Sergiy M. Kovalenko; Svitlana V. Shishkina; Oleg V. Shishkin; Valentin P. Chernykh

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 185 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.219

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✦ Synopsis

Abstract

magnified image The interaction of both 2‐iminocoumarin‐3‐carbonitriles and 2‐iminocoumarin‐3‐carbothioamides with 2‐aminothiophen‐3‐carboxamides lead to formation of 3‐(4‐oxo‐3,4‐dihydrothieno[2,3‐d]pyrimidin‐2‐yl)‐2‐iminocoumarins in two steps. The simplicity of the procedure, as well as the high yields of the target products make this method to be a good alternative of Knoevenagel condensation for the synthesis of 3‐(4‐oxo‐3,4‐dihydrothieno[2,3‐d]pyrimidin‐2‐yl)‐2‐iminocoumarins. J. Heterocyclic Chem., (2010).

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