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One-pot Synthesis of 2,4-Diamino-substituted Thieno[3,2-d]pyrimidines

✍ Scribed by Xiaoying Li; Yangming Zhang; Jie Tang; Fan Yang; Fajun Nan


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
44 KB
Volume
28
Category
Article
ISSN
0256-7660

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Synthese von 2,4-Diamino-thieno[2,3-d]py
✍ Helmut Link πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 German βš– 424 KB

Synthesis of 2,4‐Diamino‐thieno[2,3‐__d__]pyrimidines Condensation of 2‐aminothiophene‐3‐carbonitrile (4) with guanidine or sequential addition of CS~2~ and NH~3~ to 4 provides 2,4‐diaminothieno[2,3‐__d__]pyrimidine (7). This compound yields, after sequential addition of __sec__‐BuLi and either [3‐