Synthesis of 4-Hydroxy-4-methylcyclohex-2-en-1-one.
✍ Scribed by Vesile Parladar; M. Serdar Gueltekin; Murat Celik; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 21 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The title compound __R__‐4a was prepared from (–)‐quinic acid (1) in 6 steps in 18% overall yield (Scheme 3) and with 100% enantiomeric purity (Figure 1). The initiating step is the regio‐ and stereoselective acetalization of the __trans__‐oriented vicinal OH groups of 1 (+ 5 → 8). Alco
## Abstract 3‐Acetyl‐4‐hydroxy‐chromen‐2‐one (**1**) was brominated with phenyltrimethylammonium tribromide to afford 3‐(2‐bromoacetyl)‐4‐hydroxy‐chromen‐2‐one (**2**) whose reactions with thiourea, thioacetamide and ammonium dithiocarbamate gave respectively 3‐(2‐amino‐thiazol‐4‐yl)‐4‐hydroxy‐, 4‐
## Abstract 1‐[2‐hydroxy‐4‐(3‐sulfo‐1‐propyloxy)‐phenyl]‐3‐ ‐(3‐hydroxy‐4‐methoxyphenyl)‐propan‐1‐one sodium salt labelled with ^14^C at its carbonyl group (__1__) was synthetized starting from sodium acetate‐1‐^14^C through acetyl chloride‐1‐^14^C, resacetophenone‐carbonyl‐^14^C (__2__), 2‐hydroxy
14.9 (q).