Synthesis of 4-hydroxy-2,5-dimethylfuran-3(2H)-one (furaneol) from (2R,3R)-tartaric acid
✍ Scribed by Briggs, Mark A.; Haines, Alan H.; Jones, Haydn F.
- Book ID
- 111926788
- Publisher
- Royal Society of Chemistry
- Year
- 1985
- Weight
- 634 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1472-7781
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📜 SIMILAR VOLUMES
## Abstract Starting from __R__,__R__‐(+)‐tartaric acid, the synthesis of (2__S__,3__R__,4__R__6__E__)‐3‐hydroxy ‐4‐methyl‐2‐methylamino‐6‐octenoic acid in 24 steps is reported. This novel amino acid is found in the cyclic undecapeptide cyclosporin A, isolated from the fungal strain __Tolypocladium
## Abstract magnified image A simple preparation of ethyl 2,5‐dimethylfuran‐3‐carboxylate (**3**), 2,5‐dimethylfuran‐3,4‐dicarboxylic acid (**4**), and diethyl 2,5‐dimethylfuran‐3,4‐dicarboxylate (**5**) by treatment of diethyl 2,3‐diacetylsuccinate (**2**) with aqueous HCl is reported. The reacti