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Synthesis of 4′-aminopantetheine and derivatives to probe aminoglycoside N-6′-acetyltransferase

✍ Scribed by Yan, Xuxu; Akinnusi, T. Olukayode; Larsen, Aaron T.; Auclair, Karine

Book ID
118210292
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
398 KB
Volume
9
Category
Article
ISSN
1477-0520

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Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases
✍ Feng Gao; Xuxu Yan; Oliver M. Baettig; Albert M. Berghuis; Karine Auclair 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB

Aminoglycosides are among the most commonly used broadspectrum antibiotics. [1] The biological activity relies on their high affinity for the major groove of bacterial 16S rRNA, [2] thereby impeding protein synthesis. A number of aminoglycosides also display antiviral activity owing to specific inte