Synthesis of nornicotine-2,4,5,6-d4 and its N′-nitroso derivative
✍ Scribed by James W. Munson; Thomas G. Hodgkins
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 343 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2135
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## Abstract Using commercially available paraformaldehyde–d~2~, the subject compounds were synthesized with unlabeled reactants and ordinary solvents. The 2,2–dinitropropane–1,3‐diol–1,1,3,3–d~4~ (ADIOL–d~4~) precursor was produced in greater than 99% isotopic purity with aqueous depolymerized para
## 4 Cholesterol-3,4-d and -2,2,4,4,6-d5 have been synthesized from A - 2 cholestene-3-one for use as mass spectrometric stable isotope internal standards. Conversion of A -cholesten-3-one to the enol acetate followed by reduction with sodium borodeuteride in a deuterated solvent yielded cholester