Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor
โ Scribed by Sunderland, Peter T. ;Dhami, Archana ;Mahon, Mary F. ;Jones, Louise A. ;Tully, Sophie R. ;Lloyd, Matthew D. ;Thompson, Andrew S. ;Javaid, Hashim ;Martin, Niall M. B. ;Threadgill, Michael D.
- Book ID
- 118209604
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 421 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1477-0520
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## Abstract Electrical energy offers numerous benefits for conducting a synthesis, including increased reaction rates, yield enhancements and cleaner chemistries. 5-Aryl-2-(arylamino)-1,3,4-oxadiazoles were synthesised directly from acylthiosemicarbazide on the platinum electrode under controlled p
We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl