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A new convenient synthesis of 5-aryl-2-(arylamino)-1,3,4-oxadiazole derivatives

✍ Scribed by Sanjeev Kumar


Book ID
111491554
Publisher
Versita
Year
2012
Tongue
English
Weight
140 KB
Volume
66
Category
Article
ISSN
0366-6352

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✦ Synopsis


Abstract

Electrical energy offers numerous benefits for conducting a synthesis, including increased reaction rates, yield enhancements and cleaner chemistries. 5-Aryl-2-(arylamino)-1,3,4-oxadiazoles were synthesised directly from acylthiosemicarbazide on the platinum electrode under controlled potential electrolysis in an undivided cell assembly in acetonitrile.


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Thermolysis of 3-phenyl-5-arylamino-1,2,
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Thermal reactions of 3-phenyl-5-arylamino-1,2,4-oxadiazoles I and II were investigated. Neat heating at ca. 250ЊC for 6 hours afforded H 2 O, benzonitrile, arylcyanamides, arylamines, azobenzene, benzimidazole derivatives, and 3,3Ј-diphenyl-5,5Ј-bis[1,2,4-oxadiazolyl]. Analogous results were obtaine

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