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Synthesis of [4″-3H]- and [4,4,5,5-2H4]-2-(1′-[2′,6″-Dichlorophenoxy]-ethyl)-Δ2-imidazoline

✍ Scribed by Gerd Kloster; Johannes Odenthal

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
205 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[4″‐^3^H]‐2‐(1‐[2″,6″‐Dichlorophenoxy]‐ethyl‐Δ^2^‐imidazoline) was prepared from [4‐^3^H]‐2,6‐dichlorophenol in two different ways. By reaction of 2,6‐dichlorophenol with 2‐(α‐chloroethyl)‐Δ^2^‐imidazoline, the radiochemical yield, at a specific activity of 173.9 mCi/mmole, was 12.8 %. With the two‐step‐procedure (reaction of 2,6‐dichlorophenol with 1.) 2‐chloropropionitrile and 2. ethylenediamine, the radiochemical yield of product, at a specific activity of 185.8 mCi/mmole, was 30.0 %.

[4,4,5,5‐^2^H~4~]‐2‐(1′‐[2″,6″‐Dichlorophenoxy]‐ethyl)‐Δ^2^‐imidazoline was prepared in one step from [1,1,2,2‐^2^H~4~]‐ethylene‐diamine in 49 % yield.

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