✦ LIBER ✦

Synthesis of [4-14C]diosgenin

✍ Scribed by E. S. Ferdinandi

Publisher: John Wiley and Sons
Year: 1979
Tongue: French
Weight: 211 KB
Volume: 16
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580160214

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✦ Synopsis

Abstract

[4‐^14^C]‐(25R)‐Spirost‐5‐en‐3β‐ol(diosgenin)l, specific activity 3.77 ± 0.02 mCi/mmole, was synthesized in four stees from (25R)‐5‐hydroxyspirost‐5‐en‐3‐oic‐3,5‐lactone 4 and [^14^C] methyl magnesium iodide with an overall yield of 18%. The preparation of the starting lactone from diosgenin is also described.

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