Synthesis of [3H2]-(R,R)-1,2-diaminocyclohexaneoxalatoplatinum(II), [3H2]-Oxaliplatin
β Scribed by Alain Burgos; George J. Ellames
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 234 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
Some L-aspartylnorbornylamino alcohol derivatives were synthesized as potential peptide sweeteners. Of these compounds, 3-(~-aspartylamino)-l-(3-methyl-2-norbornyl)-2-butanol displays an excellent sweetness potency. By further synthesis of one diastereoisomer, (2R,3R)-3-(~-aspartylamino)-1-[(2S,3R)-
2-Ethoxy-1-methyl-5-pymlidinone (1) was reacted with ethyl [3,4-'3C2]acetoacetate (2) in the presence of T i c 4 to give ethyl [3,4-13C2]-2-( 1'-methyl-5'oxo-2'-pyrrolidinyl)-3-oxobutanoate (3) in 85% yield. Decarboethoxylation of ethyl [3,4-13C2]-2-( l'-methyl-5'-oxo-2'-pyrrolidiny1)-3-oxobutanoate