Synthesis of 3H-(–)-galanthamine
✍ Scribed by Elmar Linnemann; Gregor Fels
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 113 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.500
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✦ Synopsis
Abstract
^3^‐(–)‐galanthamine (0.881 TBq/mmol) was synthesized via stereoselective reduction of (–)‐narwedine with tritiated L‐Selectride^®^. This reaction sequence was favored over an exchange of aromatic bromine with lithium aluminium tritide. Copyright © 2001 John Wiley & Sons Ltd.
📜 SIMILAR VOLUMES
## Abstract The synthesis of deuterium‐labelled galanthamine is reported. 6‐[^2^H~3~]methoxy‐__N__‐[^2^H~3~]methyl‐(−)‐galanthamine was obtained in seven steps from galanthamine. The synthesis was carried out by selective __O__‐ and __N__‐demethylations. The [^2^H~3~]‐__N__‐methyl and [^2^H~3~]‐__O