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Synthesis of [35s]-labelled MK-0571, a potent antagonist of LTD4

✍ Scribed by Haydn W. R. Williams; Robert N. Young; Robert Zamboni; D. R. D. Shaw

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
360 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 5‐[3‐{2‐(7‐chloroquinolin‐2‐yl)ethenyl}‐phenyl]‐8‐dimethylcarbamyl‐4,6‐[6‐^35^S]dithiaoctanoic acid at a specific activity of 1350 Ci/mmol is reported. This compound is a reagent suited for selective affinity binding studies at the LTD~4~ receptor.

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