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Synthesis of [3,5-dichlorobenzenesulfonamide-U-14C)] labeled VLA-4 antagonists

✍ Scribed by Nathan X. Yu; Conrad E. Raab; Dennis C. Dean; Linus S. Lin; David G. Melillo

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
128 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Radiolabeled tracers were required for the development of a series of VLA‐4 antagonists. A method to synthesize [U‐^14^C]3,5‐dichlorobenzenesulfonyl chloride was developed. From this key intermediate, various tracers were prepared in high yield. Copyright © 2004 John Wiley & Sons, Ltd.

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