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Synthesis of 3- and 21-monosulfates of [2,2,3β,4,4-2H5]-tetrahydrocorticosteroids in the 5β-series as internal standards for mass spectrometry

✍ Scribed by Shigeo Ikegawa; Kaori Nagae; Takayuki Mabuchi; Rika Okihara; Maki Hasegawa; Toshie Minematsu; Takashi Iida; Kuniko Mitamura


Book ID
116892649
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
435 KB
Volume
76
Category
Article
ISSN
0039-128X

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## Abstract Deuterium Labelled 5‐hydroxyindole‐3‐acetic acid and 5‐hydroxy‐tryptamine have been sythesized by a modification of the procedure previously described by Ek and Witkop (9) for the nondeuterated analogues. The deuterium is introduced by a solvent exahange reaction and by reduction with l