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Synthesis of 3′-Amino-3′-Deoxyguanosine and 3′-Amino-3′-Deoxyxyloguanosine Monophosphate Hepdirect Prodrugs from Guanosine
✍ Scribed by Bookser, Brett C.; Raffaele, Nicholas B.; Reddy, K. Raja; Fan, Kevin; Huang, Wenjian; Erion, Mark D.
- Book ID
- 118210379
- Publisher
- Taylor and Francis Group
- Year
- 2009
- Tongue
- English
- Weight
- 624 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0732-8311
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## Abstract 3′‐Amino‐3′‐deoxyguanosine was synthesized from guanosine in eight steps and 58% overall yield. The 2′,3′‐diol of 5′‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐__N__‐[(dimethylamino)methylidene]guanosine was reacted with __α__‐acetoxyisobutyryl bromide and treated with 0.5n NH~3~ in MeOH t
Highly efficient synthesis of protected 3%-deoxyadenosine and 3%-deoxyguanosine from adenosine and guanosine were described. The 2%,3%-diol of protected adenosine and guanosine were reacted with a-acetoxyisobutyryl bromide to yield 9-(2%-Oacetyl-3%-bromo-5%-O-tert-butyldiphenylsilyl-3%-deoxy-b-D-xyl