## Abstract 3′‐Amino‐3′‐deoxyguanosine was synthesized from guanosine in eight steps and 58% overall yield. The 2′,3′‐diol of 5′‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐__N__‐[(dimethylamino)methylidene]guanosine was reacted with __α__‐acetoxyisobutyryl bromide and treated with 0.5n NH~3~ in MeOH t
ChemInform Abstract: Synthesis of 3′-Amino-3′-deoxyguanosine and 3′-Amino-3′-deoxyxyloguanosine Monophosphate Hepdirect Prodrugs from Guanosine.
✍ Scribed by Brett C. Bookser; Nicholas B. Raffaele; K. Raja Reddy; Kevin Fan; Wenjian Huang; Mark D. Erion
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 20 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Synthesis of (-)-3-Amino-3-deoxyquinic Acid. -The title acid (X) is prepared in nine steps from quinic acid (I) in 14% overall yield. Its importance for the biosynthesis of 3-amino-5-hydroxybenzoic acid, the precursor of mC 7 N-units in ansamycin and mitomycin antibiotics is discussed. -
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v