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Analogs of the Aminonucleoside Derived from Puromycin. The Synthesis of 3'-Amino-3'-deoxyguanosine and 3'-Amino-3'-deoxycrotonoside

✍ Scribed by Kissman, Henry M.; Small Hoffman, Arlene; Weiss, Martin J.


Book ID
126241985
Publisher
American Chemical Society
Year
1963
Tongue
English
Weight
413 KB
Volume
6
Category
Article
ISSN
0022-2623

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An Efficient Synthesis of 3β€²-Amino-3β€²-de
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## Abstract 3′‐Amino‐3′‐deoxyguanosine was synthesized from guanosine in eight steps and 58% overall yield. The 2β€²,3′‐diol of 5′‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐__N__‐[(dimethylamino)methylidene]guanosine was reacted with __Ξ±__‐acetoxyisobutyryl bromide and treated with 0.5n NH~3~ in MeOH t

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