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Synthesis of 3-(4-Pyridinyl)-, 3-(2-Chloro-4-pyridinyl)- and 3-(2-Amino-4-pyridinyl)propoxymethanephosphonic Acid

✍ Scribed by Krečmerová, Marcela; Holý, Antonín; Masojídková, Milena

Book ID
111671395
Publisher
UOCHB
Year
1995
Tongue
English
Weight
111 KB
Volume
60
Category
Article
ISSN
0010-0765

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A new efficient method for the preparation of 3-(4-pyridinyl)methylindoles has been developed. The new method involves coupling of indoles with 4-pyridinecarboxaldehyde to give 3-indolyl 4-pyridinyl methanols, which upon treatment with triethylsilane in the presence of trifluoroacetic acid afford 3-