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A new efficient synthesis of 3-(4-pyridinyl)methylindoles

✍ Scribed by Ping Zhou; Yanfang Li; Kristin L Meagher; Richard G Mewshaw; Boyd L Harrison

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
52 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new efficient method for the preparation of 3-(4-pyridinyl)methylindoles has been developed. The new method involves coupling of indoles with 4-pyridinecarboxaldehyde to give 3-indolyl 4-pyridinyl methanols, which upon treatment with triethylsilane in the presence of trifluoroacetic acid afford 3-(4-pyridinyl)methylindoles in 64-76% overall yield.

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