𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 3-[125I]-iodo-phencyclidine for biological studies

✍ Scribed by M. Ponchant; Y. Dreux; J. M. Kamenka; R. Chicheportiche; J. P. Beaucourt

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
257 KB
Volume
28
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

After verification of the biological activity of 3‐iodo‐PCP by binding studies to the N‐methyl D‐aspartate gated channel, 3‐[^125^I]iodo‐PCP was prepared by reaction of sodium iodide with a triazene precursor. The radiochemical yield was optimized and after HPLC purification, 3‐[^125^I]iodo‐PCP was obtained with a high radiochemical purity.

📜 SIMILAR VOLUMES

Synthesis of 5-[125I]-iodo-zacopride, a
Synthesis of 5-[125I]-iodo-zacopride, a new probe for 5-HT3 receptor binding sites
✍ M. Ponchant; T. Koscielniak; M. Hamon; H. Gozlan 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 386 KB

## Abstract In an attempt to develop a specific probe of serotonin 5‐HT~3~ receptors, various methods have been investigated to synthesize a radioiodinated derivative of the potent 5‐HT~3~ antagonist zacopride. The direct iodination of 5‐dechloro‐zacopride 2 was performed using NaI in the presence

Synthesis of 4-[2-(4-Azidophenyl)-5-(3-i
Synthesis of 4-[2-(4-Azidophenyl)-5-(3-iodo-125I-phenyl)-1H-imidazol-4-yl]pyridine (SB 206718-[125I]), a pyridinyl imidazole cytokine inhibitor
✍ Keith T. Garnes; Scott W. Landvatter; Timothy F. Gallagher 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 345 KB

The pyridinyl imidazole cytokine-suppressing anti-inflammatory drug (CSAID"), SB 206718 (1) was required in 1251-labeled form for photoaffinity ligand studies. The target compound (SB 206718-[1251], [1\*5I]l) was obtained via conversion of the highly functionalized 1 to a tributylstannyl derivative.

Radiolabelling optimization of 5-(4-[125
Radiolabelling optimization of 5-(4-[125I]-iodophenyl)-2,3 dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole or [125I]-iodo mazindol : A potential tool for spect explorations
✍ E. Galinier; J. E. Ombetta; Y. Frangin; J. Mertens; J. C. Besnard; D. Guilloteau 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 467 KB

## Abstract The radiolabelling of an iodinated analog of mazindol, 5‐(4‐[^125^I]‐iodophenyl)‐2,3‐dihydro‐5‐hydroxy‐5H‐imidazo[2,1‐a]isoindole, was performed in order to develop a potential tool for SPECT exploration of the presynaptic dopamine transporter in the human brain. Radiosynthesis was perf

Synthesis of an [125I]-labelled derivati
Synthesis of an [125I]-labelled derivative of MK-571, a tool for LTD4 receptor studies
✍ Chun-Sing Li; Yves Leblanc; Robert Zamboni; Robert N. Young 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 292 KB

## Abstract An [^125^I]‐labelled derivative of MK‐571 2 was synthesized from the arylstanne derivative 11 in 50% radiochemical yield. Compound 2 is a useful tool for LTD~4~ receptor studies. The arylstanne intermediate 11 was obtained from the coupling reaction of (±)‐3‐[[[3‐[2‐(7‐chloro‐2‐quinolin

Radiosynthesis of a photoaffinity probe
Radiosynthesis of a photoaffinity probe for the cocaine receptor of the dopamine transporter: 3β-(p-chlorophenyl)tropan-2β-carboxylic acid m-([125I]-iodo)-p-azidophenethyl ester ([125I]-RTI-82)
✍ John R. Lever; F. Ivy Carroll; Amrat Patel; Philip Abraham; John Boja; Anita Lew 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 402 KB 👁 1 views

## Abstract The tropane alkaloid RTI‐82, an iodoarylazide, has been labeled with iodine‐125 for use as a photoaffinity probe for the cocaine binding site of the dopamine transporter. The one‐flask radiosynthesis involves nocarrier‐added electrophilic radioiodination of the corresponding aniline fol