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Synthesis of (2S,3R,11S,12R,2‴R,11‴S,12‴R)-plakoside A, a prenylated and immunosuppressive marine galactosphingolipid with cyclopropane-containing alkyl chains

✍ Scribed by Masanori Seki; Akihiro Kayo; Kenji Mori

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 92 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00175-7

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✦ Synopsis

Plakoside A (1) is a prenylated galactosphingolipid isolated from the marine sponge Plakortis simplex and is strongly immunosuppressive without cytotoxicity. (2S,3R,11S,12R,2 §R,11 §S,12 §R)-plakoside A (1) was synthesized by combining sphingosine part 16, a-hydroxy acid part 24 and prenylated sugar part 29.

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