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Sunthetic Studies of Microsclerodermins. A Stereoselective Synthesis of a Core Building Block for (2 S,3 R, 4 S,5 S,6 S, 11 E)-3-Amino-6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec-11-enoic Acid (AMMTD)

✍ Scribed by Shigekazu Sasaki; Yasumasa Hamada; Takayuki Shioiri*

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
515 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A core building block 3 for (2S,3R,4S,5S,6S,l lE)-3-arnino+methyl-12-(4-merftoxyphenyl)-2,4,5-trihydmxydod&-l l-enoicacid (2, AMMTD)has beenefficientlysynthesiml using the Sharpless asymmcmicdihyrboxylationandthe Donrhri's foranadfition to a nitmne dezivadveas key steps. The2-furyl group has beenusedas the carboxylsynthon.~1997Elsevier Science Ltd.

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