Synthesis of 2s, 4s, 5s -dihydroxypipecolic acid and bulgecinine [2s,4s,5r-4-hydroxy-5- (hydroxymethyl)proline] from d-glucuronolactone, a strategy for the synthesis of 2s,4s-4-hydroxy-α-amino acids
✍ Scribed by Bharat P. Bashyal; Hak-Fun Chow; George W.J. Fleet
- Book ID
- 108372341
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 616 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
4S,5S)-5-hydroxy-4-methylpiperidine-2-one 4, readily available from Sglutamic acid, serves as a starting material for the synthesis of (2S,4S,5S)-5-hydroxy-4methylpipecolic acid 12. The key step of this reaction sequence is the chemoselective methylenation of the amide carbonyl group of 6 with dimet
A catalytic deuteration of protected 3,4-dehydro-L-proline using RuCI2(PPh3) 3 followed by RuO~-oxidation gave a 3,4-dideuterated L-pyroglutamic acid derivative which is considered to be a promising precursor for various deuterated amino acids. The present study demonstrates a stereoselective reduct