Synthesis of [3-D3]-, [3-13C]-, and [1,2
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Claude Boullais; Christelle Rannou; Emmanuel Réveillère; Charles Mioskowski
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Article
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2000
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John Wiley and Sons
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English
β 242 KB
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Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave