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Synthesis of 2,4-disubstituted N-acyl-5,6-dihydro-2-pyridones

✍ Scribed by Daniel L Comins; Xinghai Chen; Sajan P Joseph


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
150 KB
Volume
37
Category
Article
ISSN
0040-4039

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Chiral 5,6-disubstituted-5,6-dihydro-2(1H)-pyridones were prepared efficiently from readily accessible 3,4-disubstituted-2-azetidinones having preadjusted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and