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Synthesis of [2,4-bis(arylamino)thiazol-5-yl](1-methyl-1H-benzimidazol-2-yl)methanones

✍ Scribed by T. F. Abbs Fen Reji; Kallikat N. Rajasekharan

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
91 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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[2,4‐Bis(arylamino)thiazol‐5‐yl]‐(1‐methyl‐1__H__‐benzimidazol‐2‐yl)methanones, as the analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized and characterized by elemental analysis, IR, NMR, and Mass spectral data. The thiourea derivatives provide four ring atoms for the thiazole ring construction and thus act as [CNCS] synthons. The remaining carbon of the thiazole is sourced from 2‐(2‐bromoacetyl)‐1‐methyl‐1__H__‐benzimidazole. This [4+1] heterocyclization reaction is adopted for the synthesis of novel 1‐methyl‐1__H__‐benzimidazole derivatives. J. Heterocyclic Chem., (2009).

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