𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)benzimidazoles

✍ Scribed by Myung Hee Jung; Jung Mee Park; Ihl-Young Choi Lee; Mija Ahn

Publisher
Journal of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
81 KB
Volume
40
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A useful approach for the synthesis of pharmacologically active tetrahydropyridinylbenzimidazoles is described. 2‐Pyridin‐3‐ylbenzimidazoles 3a‐d have been synthesized by condensation of 3‐pyridinecarbox‐aldehyde 1 with substituted 1,2‐phenylenediamines 2a‐d following oxidative cyclization with iodobenzene diacetate. Methylation of 3a‐d with iodomethane and potassium hydroxide, subsequent formation of methylpyridinium salts 4a‐d and 7a‐d and reduction thereafter afforded tetrahydropyridinylbenzimidazoles 5a‐d and 8a‐d.

📜 SIMILAR VOLUMES

Synthesis of [2,4-bis(arylamino)thiazol-
Synthesis of [2,4-bis(arylamino)thiazol-5-yl](1-methyl-1H-benzimidazol-2-yl)methanones
✍ T. F. Abbs Fen Reji; Kallikat N. Rajasekharan 📂 Article 📅 2009 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 91 KB

## Abstract magnified image [2,4‐Bis(arylamino)thiazol‐5‐yl]‐(1‐methyl‐1__H__‐benzimidazol‐2‐yl)methanones, as the analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized and characterized by elemental analysis, IR, NMR, and Mass spectral data. The thiourea derivatives provide four r