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ChemInform Abstract: Synthesis of 2-Substituted-1-[(2′-carboxybiphenyl-4-yl)methyl]benzimidazoles.

✍ Scribed by Preet Mohinder Singh Bedi; Raman K. Verma; Manjeet Singh


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


Synthesis

of 2-Substituted-1-[(2'-carboxybiphenyl-4yl)methyl]benzimidazoles.

-The title benzimidazole analogues of EXP 7711 such as (VII) are prepared as potential balanced antagonists of AT 1 and AT 2 receptors. -(BEDI,


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## Abstract Forty‐three 2‐[(benzotriazol‐1/2‐yl)methyl]benzimidazoles, bearing either linear (dialkylamino)alkyl‐ or bulkier (quinolizidin‐1‐yl)alkyl moieties at position 1, were evaluated in cell‐based assays for cytotoxicity and antiviral activity against viruses representative of two of the thre