Synthesis of 2,2-dimethyl-1-carbapenam derivatives via an intramolecular michael-type reaction
β Scribed by Masayuki Shibuya; Masahiko Kuretani; Seiju Kubota
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 252 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Solid phase intramolecularHeck couplingallows the syothesisof 2-oxindoles. Additional diversityis introducedinfo the moleculeby reductiveatkylationprior to the Heck cyclisationarrdatso by conjugateadditionof a varietyof nucleophilesontothe cyctisedproductprior to cleavage. 01997 Elsevier ScienceLtd.
The palladium(0)-catalyzed reaction of derivatives of g-amino-a,b-unsaturated esters bearing an N-(2-iodobenzoyl) substituent results in an intramolecular Heck reaction, the outcome of which depends on the structure of the substrate as well as on the experimental conditions. The methodology develope