𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 20-[18F]fluoroarachidonic acid: A potential phospholipid metabolic agent

✍ Scribed by Fumi Nagatsugi; Junji Hokazono; Shigeki Sasaki; Minoru Maeda

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
422 KB
Volume
34
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A fluorine‐18 labelled analog of arachidonic acid, 20‐[^18^F]fluoroarachidonic acid, was prepared for evaluation as a potential phospholipid metabolic agent.

The radiosynthesis was accomplished by [^18^F]fluoride ion displacement on the tosylate precursor followed by basic hydrolysis of the ester group, in isolated radiochemical yield (not decay corrected) of 10 % in overall synthesis time (including HPLC purification) of 110 min.

📜 SIMILAR VOLUMES

Synthesis of a [18F]fluorobenzothiazole
Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent
✍ Ursula Berndt; Christian Stanetty; Thomas Wanek; Claudia Kuntner; Johann Stanek; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 266 KB

## Abstract This study describes the synthesis of a fluoroethylated derivative of [__N__‐methyl‐^11^C]2‐(4′‐methylaminophenyl)‐6‐hydroxybenzothiazole ([^11^C]6‐OH‐BTA‐1; Pittsburgh Compound B (PIB)), an already established amyloid imaging agent. The [^11^C]methylamino group of [^11^C]6‐OH‐BTA‐1 was

A rapid synthesis of [fluoroacetyl-18F]f
A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (Nω-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent
✍ Masao Tada; Ren Iwata; Hiroshi Sugiyama; Kazunori Sato; Claudio Pascali; Hiroshi 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 334 KB

## Abstract An efficient synthesis of [__fluoroacetyl__‐^18^F]fluoromelatonin (__N__ω‐[^18^F]Fluoroacetyl‐5‐methoxytryptamine) starting from [^18^F]fluoride and ethyl __p__‐toluensulfonyloxyacetate is described. The total time required for its synthesis is __ca.__ 90 min. The radiochemical yield, p

Synthesis of [18F]Fluoroclofilium as a p
Synthesis of [18F]Fluoroclofilium as a potential cardiac imaging agent for PET studies
✍ K. H. Yu; Y. S. Kim; S. W. Kim; J. H. Park; S. D. Yang; W. Herdering; A. Knoeche 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB

## Abstract __N__‐4‐(4‐chlorophenyl)butyl‐__N__,__N__‐diethyl‐7‐[^18^F]fluoroheptylammonium ([^18^F]‐fluoroclofilium) has been prepared as a potential cardiac imaging agent. For the synthesis of this radiolabelled ammonium salt, its tosyloxylated analogue was prepared as a precursor, and the non‐ra

Synthesis of 18F-labeled cyclooxygenase-
Synthesis of 18F-labeled cyclooxygenase-2 (COX-2) inhibitor as a potential PET imaging agent
✍ Haibin Tian; Zhenghong Lee 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 144 KB

A new PET tracer for COX-2 imaging, the 6-ethoxy-3-(4-methanesulfonylphenyl)-4-(4-[ 18 F]fluorophenyl)pyran-2-one ([ 18 F]EFMP), was synthesized. For F-18 radiolabeling, a trimethylammonium precursor and a brominated precursor were synthesized from 1,1,2,3-tetrachlorocycloprop-2-ene in 6 steps. The