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A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (Nω-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

✍ Scribed by Masao Tada; Ren Iwata; Hiroshi Sugiyama; Kazunori Sato; Claudio Pascali; Hiroshi Fukuda; Kazuo Kubota; Roko Kubota; Hiromu Takahashi; Akira Wakui; Yoshinao Abe; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
334 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient synthesis of [fluoroacetyl‐^18^F]fluoromelatonin (__N__ω‐[^18^F]Fluoroacetyl‐5‐methoxytryptamine) starting from [^18^F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

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