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Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

✍ Scribed by Baris Ilkgul; Deniz Gunes; Okan Sirkecioglu; Niyazi Bicak

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 271 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.07.167

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✦ Synopsis

A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75-94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240-260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.

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