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Synthesis of 2-(N-benzylpyrrolyl)-benzimidazoles using polyphosphoric acid prompted cyclocondensation

✍ Scribed by Bereket Mochona; Laine Le; Madhavi Gangapuram; Nelly Mateeva; Tiffany Ardley; Kinfe K. Redda

Book ID
102344959
Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
96 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image Synthesis of a series of 2‐substituted benzimidazoles was carried out for screening anti‐inflammatory activities. 2‐(N‐benzylpyrrolyl)‐benzimidazoles 9a, 9b, 9c, 9d, 9e, 9f, 9g, 9h, 9i, 9j, 9k were synthesized from N‐benzyl‐2‐pyrrole carboxylic acids 8a, 8b, 8c, 8d and 4‐substituted‐1,2‐phenylenediamines by cyclocondensation utilizing polyphosphoric acid (PPA) as condensing agent. The N‐benzyl‐2‐pyrrole carboxylic acids were prepared by standard method of N‐benzylation of 2‐pyrrole carboxylate using NaH/DMF and appropriately substituted benzyl halides followed by alkaline hydrolysis. J. Heterocyclic Chem., (2010).

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