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Synthesis of 2-heteroaryl-3-hydroxypyridines by ring expansion reactions of 2-acylfurans with ammonia

✍ Scribed by Chubb, Richard W. J.; Bryce, Martin R.; Tarbit, Brian


Book ID
115454129
Publisher
Royal Society of Chemistry
Year
2001
Weight
68 KB
Volume
16
Category
Article
ISSN
1472-7781

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## Abstract (__S__)‐5‐Benzoyloxymethyl‐3‐[(__E__)‐(dimethylamino)methylidene]tetrahydrofuran‐2‐one (6), prepared in 5 steps from L‐glutamic acid (1), was used as precursor in a one step ‘ring switching’ synthesis of (__S__)‐2‐hydroxy‐3‐heteroaryl‐l‐propyl benzoates **13‐18, 23, 24.** In the reactio