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ChemInform Abstract: Synthesis of (S)-3-Heteroaryl-2-hydroxy-1-propyl Benzoates by ′Ring Switching′ Methodology.

✍ Scribed by Damjana Mihelic; Renata Jakse; Jurij Svete; Branko Stanovnik; Simona Golic Grdadolnik

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
33
Category
Article
ISSN
0931-7597

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Synthesis of (S)-3-heteroaryl-2-hydroxy-
Synthesis of (S)-3-heteroaryl-2-hydroxy-l-propyl benzoates by ‘ring switching’ methodology
✍ Damjana Mihelič; Renata Jakše; Jurij Svete; Branko Stanovnik; Simona GoliČ Grdad 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 88 KB

## Abstract (__S__)‐5‐Benzoyloxymethyl‐3‐[(__E__)‐(dimethylamino)methylidene]tetrahydrofuran‐2‐one (6), prepared in 5 steps from L‐glutamic acid (1), was used as precursor in a one step ‘ring switching’ synthesis of (__S__)‐2‐hydroxy‐3‐heteroaryl‐l‐propyl benzoates **13‐18, 23, 24.** In the reactio